Table 1.
Kv3.4 biophysical properties after laminectomy and SCI
| Naïve | 1 week | 2 weeks | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Laminectomy | SCI | Laminectomy | SCI | |||||||
| N | N | N | N | N | ||||||
| Activation | ||||||||||
| V1/2 (mV) | 16.8 ± 4.8 | 18 | 11.1 ± 6.2 | 19 | 11.4 ± 4.3 | 18 | 19.1 ± 3.8 | 24 | 11.0 ± 4.5 | 24 |
| Vs (mV) | -25.5 ± 3.3 | 18 | -26.2 ± 6.2 | 19 | -29.2 ± 3.7 | 18 | -27.5 ± 4.3 | 24 | -30.2 ± 3.8 | 24 |
| zGp (e0) | 1.01 ± 0.09 | 18 | 1.14 ± 0.13 | 19 | 1.05 ± 0.13 | 18 | 0.91 ± 0.08 | 24 | 1.03 ± 0.09 | 24 |
| Inactivation | ||||||||||
| V1/2 (mV) | -30.1 ± 1.6 | 18 | -41.0 ± 2.6 | 14 | -31.6 ± 2.2 | 14 | -33.9 ± 0.7 | 11 | -29.0 ± 2.1 | 9 |
| zssi (e0) | 3.40 ± 0.58 | 18 | 2.95 ± 0.79 | 14 | 2.30 ± 0.41 | 14 | 2.32 ± 0.14 | 11 | 2.05 ± 0.31 | 9 |
| zTaui (e0) | 1.51 ± 0.07 | 17 | - | - | 1.27 ± 0.31 | 21 | - | |||
-
All parameters were calculated as described in Materials and Methods. For z, the subscripts indicate the parameter from which the z was calculated. Gp, Peak chord conductance relation; ssi, steady-state inactivation curve; Taui, time constant of inactivation. For some groups an exponential fit to the Taui-V relation could not be obtained and thus zTaui could not be determined.